Therapeutic drug monitoring in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a problem that directly affects the quality of life of patients suffering from this condition. Monitoring the serum level of infliximab (IFX) (TDM) is an important tool for guiding therapeutic decisions in IBD patients. The purpose of this study was to determine the significance of quantitatively measuring the serum level of IFX (TDM) and antibody to IFX (ATI). Methods and materials: Prospective observational study involving 40 IBD patients on IFX therapy, including 14 Proactive (week 06 of the induction phase) and 26 Reactive (maintenance phase). Immediately prior to the infusion, blood samples were drawn and measured using a Bulhlmann rapid test instrument. Serum concentrations of IFX were categorized as supratherapeutic (>7.0 micrograms/ml), therapeutic (between 3.0 and 7.0 micrograms/ml), and subtherapeutic (3.0 micrograms/ml). When the serum concentration of IFX was 3 mcg/ml (subtherapeutic), the ATI was measured. 25 patients with CD and 15 patients with UC were evaluated. Only three of the twenty patients with subtherapeutic serum levels had a positive ATI, and both were reactive; two had CD and one had UC. There was a statistically significant difference between reactive and proactive patients with respect to levels of CRP (p = 0.042), with proactive DNS patients suffering greater alterations in CRP and albumin. (AU)

Watch and wait, worth It?

Background: The surgery with total mesorectal excision recommended by R. J. Heald in 1982 is the gold standard. Rectal cancer (RC) surgery has a morbidity rate ranging from 6 to 35%, and it can cause functional issues such as sexual, urinary, and bowel dysfunction in the long term. Neoadjuvant chemoradiotherapy (CRT) has been gaining ground in patients with lesions in the middle and lower rectum. The aim of the present study is to present the experience of a reference service in the treatment of RC. Patients and Methods: A retrospective study involving 53 patients diagnosed with RC between January 2017 and December 2019 with follow-up until December 2020. We examined tumor location, disease stage, digital rectal exam findings, carcinoembryonic antigen (CEA), therapeutic modality offered, and follow-up time. Results: A total of 32% of the patients were men and 68% were women, with a mean age of 60 years old. Location: upper rectum in 6 cases, middle rectum in 21 cases, and lower rectum in 26 cases with evolution from 9.8 to 13.5 months. The most frequent complaints were hematochezia and constipation. A total of 36 patients underwent neoadjuvant therapy: 11 complete clinical response (CCR) (30.5%), 20 (55.5%) partial clinical response (PCR), and no response in 5 patients (14%). The follow-up ranged from 12 to 48 months, with a mean of 30.5 months. A total of 25% of the patients had RC that went beyond the mesorectal fascia, and 22.64% had metastases in other parts of the body when they were diagnosed. Conclusion: Neoadjuvant radio and chemotherapy present themselves as an alternative in the treatment of rectal cancer. In 36 patients, 30.5% had a complete clinical response, 55.5% had a partial clinical response, and 14% had no response. It was worth doing the "Watch and Wait" (W&W) to sample. A definitive colostomy was avoided. However, it is necessary to expand the study to a larger follow-up and more patients. Additionally, it is necessary to implement a multicenter study. (AU)

O estudo da representação anatômica do músculo latíssimo do dorso e a sua aplicação em cirurgia plástica / Anatomical representation of the latissimus dorsi and its application in plastic surgery

INTRODUÇÃO: O músculo latíssimo do dorso (MLD) é um importante elemento da parede látero-posterior do tórax. A aplicabilidade do MLD em cirurgia plástica é reconhecida por sua anatomia constante, sendo indicado, na reconstrução mamária, na microcirurgia, nas reconstruções de membros superiores, entre outros, tornando-se um retalho versátil em cirurgia reconstrutora. Sua representação em livros e estudos anatômicos apresentam controvérsias. Mathes & Nahai expressam que a posição do MLD é configurada em uma localização onde o músculo encontra-se em segmento torácico látero-posterior, mas com uma representação mais posterior que lateral. Um grande número de anatomistas escreve da mesma forma. O objetivo é o de discutir e descrever a real posição do MLD por meio do estudo da sua anatomia e comparação com imagens publicadas em livros. MÉTODOS: Estudou-se a descrição e representação anatômica do MLD em desenhos publicados em livros e artigos de autores clássicos. Os desenhos foram comparados com o estudo da anatomia vásculo-nervosa e muscular do MLD durante a dissecção, na posição de Decúbito Dorsal (DD), de 47 cadáveres frescos. RESULTADOS: O estudo da descrição e representação anatômica do MLD em livros de autores consultados, comparada com a dissecção em DD de cadáveres frescos, permitiu conhecer que estes autores identificam o MLD em uma posição mais posterior do que a encontrada na anatomia. CONCLUSÃO: Este estudo identifica a posição do MLD com uma representação mais anterior do que os desenhos dos livros estudados. A rotação e individualização do MLD com o paciente em decúbito dorsal é uma abordagem segura.

INTRODUCTION: The latissimus dorsi muscle (LDM) is an important element in the lateroposterior wall of the thorax. The LDM is valued in plastic surgery for its constant anatomy, and its use is recommended for mammary reconstruction, microsurgery, and upper limb reconstruction among other procedures, which makes it a versatile flap for reconstructive surgery. However, its representation in books and anatomical studies is controversial. Mathes & Nahai described that the position of the LDM is configured in a location where the muscle is found in the lateroposterior thoracic segment but with a more posterior than lateral representation. A great number of anatomists share the same opinion. The objective of this study was to discuss and describe the real position of the LDM through study of its anatomy and comparison with images published in books. METHODS: We studied the anatomical description and representation of the LDM in drawings published in books and articles by classical authors. The drawings were compared with the neurovascular and muscular anatomy of the LDM during its dissection from 47 fresh cadavers in the dorsal decubitus (DD) position. RESULTS: Study of the anatomical description and representation of the LDM in the revised books compared with the dissection of fresh corpses in the DD position revealed that the published authors described the LDM in a more posterior position than that found in the body. CONCLUSION: This study identified the LDM position as being more anterior than that described by drawings in published books. LDM rotation and individualization with the patient in a DD position is a safe approach.

A sistematização do retalho do músculo latíssimo do dorso em decúbito dorsal / The formation of the latissimus dorsi muscle flap in the dorsal decubitus position

Introdução: O músculo latíssimo do dorso localiza-se na parede latero-posterior do tórax. O retalho do músculo latíssimo do dorso (RMLD) tem uma extensa aplicabilidade devido a sua anatomia pouco variável contribuindo, assim, para sua utilização em Cirurgia Plástica. A possibilidade de dissecar este músculo em decúbito dorsal (DD) dispensa a mudança de posição do paciente e cria uma opção para reconstruções microcirúrgicas. Este estudo objetiva sistematizar a técnica utilizada para dissecção do RMLD em DD. Método: Foram avaliados 10 casos de RMLD realizados no Hospital Universitário da Universidade Federal de Alagoas, os procedimentos cirúrgicos de individualização dos retalhos e seu posicionamento na região receptora foram semelhantes nos dez casos. É realizada a avaliação do músculo e a demarcação do retalho com o paciente em pé. Depois, com o paciente em DD, faz-se a indução anestésica e a preparação do campo a ser operado. Faz a abordagem do pedículo vásculo-nervoso por incisão na margem superior da elipse que delimita o RMLD, secciona o tendão de inserção do músculo e retira-se o retalho necessário à área receptora a ser reconstruída. Resultados: A posição do paciente no intraoperatório foi o DD, inclusive durante a dissecação dos retalhos musculares, e a técnica utilizada não proporcionou desvantagens do ato cirúrgico. Conclusão: É possível realizar a dissecção e individualização do RMLD estando o paciente em DD.

Introduction: The latissimus dorsi muscle is located on the lateral-posterior chest wall. The latissimus dorsi muscle flap (LDMF) has extensive applications due to its consistent anatomy, which contributes to its use in plastic surgery. This muscle can be dissected in the dorsal decubitus (DD) position; this removes the need for a change in patient position and enables microsurgical reconstruction to be performed. This study aimed to describe the technique used for the dissection and transfer of the LDMF in the DD position. Method: We evaluated 10 cases of LDMF formation performed in the University Hospital of the Federal University of Alagoas. The surgical procedures of individualization of the flaps and their positioning in the receiver region were similar in all ten cases. The evaluation of the muscle and the demarcation of the flap were performed with the patient in the standing position. Then, with the patient in the DD position, anesthetic induction was initiated and the operating field prepared. The neurovascular pedicle was formed by incising the top edge of the ellipse that delimits the LDMF, dissecting the insertion tendon of the muscle, and removing the flap necessary for the reconstruction of the receiver area. Results: The patient was in the DD position during the intraoperative period, even during the dissection of muscle flaps, and the technique used had no surgical disadvantages. Conclusion: It is possible to perform the dissection and individualization of the LDMF with the patient in the DD position.

Estudo morfométrico do músculo latíssimo do dorso em fetos humanos / Morphometric study of the latissimus dorsi muscle in human fetuses

Introdução: O músculo latíssimo do dorso (MLD) é largo, triangular e realiza extensão, adução e rotação medial do braço. É vascularizado pelos vasos toracodorsais e ramos perfurantes das artérias intercostais posteriores e lombares, configurando retalho tipo V de Mathes e Nahai, de grande aplicabilidade em cirurgia plástica. O objetivo é analisar a morfometria e a vascularização do MLD em fetos humanos. Método: Dissecou-se a região axilar e o MLD de oito fetos humanos formolizados (três do sexo feminino e cinco do sexo masculino), entre 20 e 32 semanas gestacionais, em decúbito dorsal e abdução completa do braço. Mensuraram-se os comprimentos dos vasos subescapulares e toracodorsais, e foi realizada a morfometria do músculo. Resultados: Em todos os fetos, os vasos toracodorsais conferiram a vascularização primária do MLD. Em 25%, a veia subescapular era tributária direta da veia axilar; 25% dos casos apresentaram veia circunflexa da escápula dupla. O ramo para o músculo serrátil anterior foi único em todos os casos. Em 50% dos casos, o ramo angular da artéria toracodorsal foi visualizado e, em 25% deles, era proveniente do ramo para o músculo serrátil anterior. A distância entre a inserção do músculo e a entrada do pedículo neurovascular variou entre 1,1 e 1,9 cm em fetos de 21 e 26 semanas, respectivamente. Todos os fetos apresentaram a margem anterior do músculo na linha axilar média. Conclusão: A morfometria constante e a reduzida variação anatômica do pedículo vascular encontradas possibilitam a realização de pesquisas envolvendo o uso do MLD em reconstruções cirúrgicas intraútero.

Introduction: The latissimus dorsi muscle (LDM) is a flat triangular muscle which extends, adducts and draws the arm medially. Its blood supply is from the thoracodorsal vessels and the perforating branches of the posterior intercostal and lumbar arteries, therefore, it is a type V flap variety, which has great applicability in plastic surgery. This study aims to analyze the morphometry and the vascularization of MLD in human fetuses. Methods: The axillary region and LDM of eight human fetuses (3 females, 5 males), between 20 and 32 weeks of gestational ages, were dissected in supine position with complete abduction of the arm. The subscapular and thoracodorsal vessels lengths were measured and the morphology of the muscle was studied. Results: In all fetuses, the dominant vascular pedicle of LDM was the thoracodorsal vessels. In 25% of cases the subscapular vein was tributary of the axillary vein. Double circumflex scapular vein were found in 25% of the cases. In all fetuses, the serratus anterior branch was unique. In 50% of the cases the angular branch of the thoracodorsal artery was found, 25% of them were from the serratus anterior branch. The length between its insertion and the entry of the neurovascular pedicle was 1.1 to 1.9 cm in fetuses of 21 and 26 weeks, respectively. In all fetuses, the anterior border of the muscle was at the mid-axillary line. Conclusion: The constant morphometry and reduced anatomical variation of the vascular pedicle enables new studies regarding the use of LDM in surgical reconstructions in utero.